produktnamn:Etelcalcetide HCL
Annat namn:Etelcalcetide hydroklorid,Etelcalcetide HCl;Etelcalcetide hydroklorid;Etelcalcetide hydroklorid (AMG-416);AMG416;KAI-4169;Parsabiv;velcalcetidhydroklorid;1262780-97-1 (fri bas)
CAS:1334237-71-6
MF:C38H74ClN21O10S2
MW:1084.71186
Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids. Etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis.
