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Pharmaceutical Peptides

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  • Product Description

Product Name:Etelcalcetide HCL

Other Name:Etelcalcetide Hydrochloride,Etelcalcetide HCl;Etelcalcetide Hydrochloride;Etelcalcetide Hydrochloride (AMG-416);AMG416;KAI-4169;Parsabiv;velcalcetide hydrochloride;1262780-97-1 (free base)

CAS:1334237-71-6

MF:C38H74ClN21O10S2

MW:1084.71186

 

Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids. Etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis.

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