Enfuvirtidacetat (T-20)
Alias:Fuzeon
Sekvens:CH3CO-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu- Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Cas nr. : 159519-65-0
Molekylär formel : C204H301N51O64
Molekylvikt : 4492
Renhet (HPLC) : 98.0%min.
Utseende : Vitt till benvitt amorft fast ämne
Enkel förorening (HPLC) : 0.5%max
Aminosyrasammansättning : ±10 % av det teoretiska
Peptidinnehåll (N%) : ≥80,0 %
Vatten innehåll (Karl Fischer) : ≤8,0 %
Innehåll av trifluoracetat(HPIC) : ≤12,0 %
FRÖKEN (ESI) : Konsekvent
Massbalans : 95.0~105,0 %
Kvalitet : Farmaceutisk kvalitet
Lagring: Stängd, Nedan 2 ~ 8℃ konservering
Användande : Behandlingsalternativ för patienter som lider av HIV/AIDS.
Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. It binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes. It works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected.
Enfuvirtide (VÄRDSHUS) is an HIV fusion inhibitor, the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It is marketed under the trade name Fuzeon (Roche).
