Desmopressin acetate is a structural analogue of natural arginine vasopressin, which is derived from two changes in the chemical structure of natural hormones, namely, 1-cysteine removal of amino groups and 8-D- Amino acid to replace 8-L-arginine. Intravenous or subcutaneous administration of dextran vasopressin 0.3ug / kg body weight increased the activity of plasma coagulation factor vIII (VIII: C) by 2-4 times; also increased the Von Willebrand factor antigen (VWF: AG) , But strong and slightly smaller. At the same time, the tissue-type plasminogen activator (t-PA) was released. The bioavailability of subcutaneous injection was about 85% of the bioavailability of intravenous injection, and the maximum plasma concentration at 0.3 ug / kg was peaked at about 60 minutes after administration, with an average of about 600 pg / ml, plasma half-life 3-4 timer, hemostatic effect depends on the plasma half-life of VIII: C, Om 8-12 timer. Oxygenated vasopressin can shorten or normalize bleeding in patients with uremia, cirrhosis, congenital or drug-induced platelet dysfunction, and bleeding in patients with unknown etiology. Patients with type IIB hemophilia Abnormal VIII factor in patients, the use of desmopressin can cause platelet aggregation or thrombocytopenia. The use of desmopressin avoids the risk of HIV or hepatitis virus infection due to the use of factor VIII concentrates.
Desmopressin Acetate can make the clinical treatment of invasive or diagnostic surgery when the bleeding time is shortened or normalized, or due to uremia, cirrhosis, congenital or drug-induced platelet dysfunction, and unknown etiology of bleeding time is too long The patient's blood is under control. This product can be used to test the dose of positive reactions in patients with mild hemophilia and hemophilia patients with small surgery bleeding control or prevention. For special cases, even for the treatment and prevention of moderate disease patients. Diabetes insipidus: adult 20 ~ 40ug / d; children 10 ~ 20ug / d, divided into 1 til 3 times taking. Enuresis: 10 ~ 40ug / d, before going to bed with. Kidney concentration test: adult 40ug, 1 year old children 10 ~ 20ug. Treatment of bleeding or preoperative bleeding prevention: intravenous 0.3ug / kg.
