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  • COA
Produk Naam Clobetasol Propionate
CAS No. 25122-46-7
Reinheid 99%
Graad Standaard Medical Standard
MF C25H32ClFO5
MW 466.97
Voorkoms Wit poeier

Clobetasol propionate is a dermatological drug. External application is suitable for chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other glucocorticoids for topical treatment of effective pruritic and non-infectious inflammatory skin diseases.

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Spesifiek, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

Item

Standaard

Resultaat
Voorkoms White or almost White crystalline powder. Wit kristallyne poeier
Identifikasie Conforms to the CRS spectrum. Conforms
Specific optical rotation +112°~ +118°(dried substance) +113.5°
Verwante stowwe

(deur HPLC)

Impurity A 0.2% maks 0.07%
Impurity B 0.3% maks 0.08%
Impurity C 0.2% maks Undetected
Impurity D 0.2% maks Undetected
Impurity E 0.5% maks 0.19%
Impurity L 0.2% maks Undetected
Impurity M 0.2% maks Undetected
Unspecified impurities 0.1% maks 0.08%
Total impurities 1.5% maks 0.48%
Loss in drying 0.5% maks 0.2%
Sulphated ash 0.1% maks 0.07%
Toets(deur HPLC) Contains 97.0% aan 102.0% of C25H32ClFO5, calculated on dried basis. 99.2%
Residual solvents Ethanol 3000ppm max 69dpm
Ace-tone 500ppm max 4dpm
Py-ridine 100 dpm 3dpm
N,N-Dimethyl formamide 100ppm max 10dpm
Afsluiting Meet the specification according to ph.Eur.8

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