BPC 157 (Body Protection Compound-157) is a 15-amino acid pentapeptide. The amino acid sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Gastric acid found in human BPC. Experiments show that BPC157 can enhance wound healing, including tendon wounds, such as rat transected Achilles tendon. The aim of this study was to investigate the possible mechanisms by which BPC 157 was used to accelerate the healing process of injured tendons. The study used two sets of tendon explants, one of which was cultured in BPC157-containing medium and the other was cultured in a medium lacking BPC 157.
Navyše, FITC-phalloidin staining demonstrated that BPC157 induced F-actin formation in fibroblasts. Similarly, Western blot analysis was able to detect the production and activation of pudding proteins and FAK proteins. Western blot analysis also showed that BPC157 increased the phosphorylation of puerarin and FAK protein without affecting the amount produced.
FITC-phalloidin staining demonstrated that BPC157 induced F-actin formation in fibroblasts. Similarly, Western blot analysis was able to detect the production and activation of pudding proteins and FAK proteins. Western blot analysis also showed that BPC157 increased the phosphorylation of puerarin and FAK protein without affecting the amount produced.
BPC 157 has a strong antiinflammatory activity in acute and chronic inflammatory models and may be an important treatment for the treatment of inflammatory bowel disease. BPC 157 shows accelerated wound healing and has significant angiogenesis. But also significantly promote the healing of rat fractures, showing osteogenesis, significantly improve the healing of segmental bone defects.BPC 157 accelerated transection rat Achilles tendon and transverse rat quadriceps muscle healing, significantly accelerated the tendon The growth of explants. The proliferation of Achilles tendon myofibroblasts derived from cultured tendon fibroblasts by MTT was not directly affected by BPC 157.
Experiments saw results with oral, peritoneal, and site injections. 10 micrograms per kg was the dose in rats for these results. This means oral or injection makes no difference, with a tiny bit of this healing becomes a whole lot easier.
