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Active Pharmaceuticals

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Product Name: Betamethasone 21-acetate
Synonyms: 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE;9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE;BETAMETHASONE 21-ACETATE;BETAMETHASONE ACETATE;9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate;Betamethasone acetate BP/USP/EP;BETAMETHASONE ACETATE EPB(CRM STANDARD)
CAS: 987-24-6
MF: C24H31FO6
MW: 434.5
EINECS: 213-578-6
Mol File: 987-24-6.mol

Betamethasone sodium phosphate and betamethasone acetate combination injection provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, lung or breathing problems, blood or bone marrow problems, eye or vision problems, lupus, serious skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Betamethasone sodium phosphate and betamethasone acetate combination is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

1.It is stronger than cortisol about methoxyflavone sugar metabolism and anti-inflammatory , amost 15 times stronger than cortisol.

2.For hydrocortisone sodium retention role,it is more than one hundred time stronger than cortisol.

3.In the primary adrenal cortical impairment of disease,it can be used for replacement therapy together with sugar corticosteroids.

4.It is also used for low renin and low aldosterone syndrome and plant nerve lesions orthostatic hypotension caused by etc.

test item standard test result
appearance white crystal or powder white crystal or powder
identification infra-red spectrum accord with normal frequency spectrum
m.p. 205°c-208°c 206.4°c
specific rotation +120°c-+128°c +125.56°c
drying loss ≥4.0% 2.18%
residue on ignition ≤0.2% 0.12%
assay 97.0%-103.0% 98.2%

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