Vardenafil
Synonyms: Vardenafil hydrochloride; Valdenafil; Valdenafil HCl, Vardenafil HCL
CAS:224785-90-4
MF: C23H33ClN6O4S
MW: 525.06
Purity: 99.91%
Standard: USP
Character: White to almost white crystalline powder, odorless, a little acerbity, soluble in water, ethanol
Usage: A selective phsphodiesterase type 5 (PDE5) inhibitor; Pharmaceutical raw material; Indicated for the treatment of erectile dysfunction(ED).
Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure). Further, Vardenafil causing lengthening of the QT interval. Therefore it should not be taken by men taking other medications that affect the QT interval (such as amiodarone).
Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the penis to help a man get and keep an erection.
This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.
Vardenafil action is just like that of tadalafil and Sildenafil. It has the ability to control over the activity of this enzyme. Vardenafil stops the activity of this enzyme and improves the blood flow to the penis which makes it firm and erect. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Erection can be easily achieved by using Vardenafil.
Test Items |
Specification |
Test Results |
Description |
White or almost white crystalline powder |
White crystalline powder |
Melting point |
191.0~193.0ºC |
192ºC |
Loss on drying |
≤1.0% |
0.5% |
Heavy metal |
≤20ppm |
15ppm |
TLC |
Only one spot |
Only one spot |
Assay |
≥99.5% |
99.91% |
Conclusion |
It complies with the USP 32 standard. |