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Pharmaceutical Peptides

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Thyrotropin TRH (Thyrotropin Releasing Hormone) (Protirelin Acetate)
Sequence: (pyro)Glu-His-Pro-NH2
Molecular formula: C16H22N6O4
Molar Mass: 362.38367 g/mol
CAS number: 24305-27-9
PubChem: CID 439302

Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary.

Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary hypothyroidism and acromegaly.

TRH is intended for intravenous administration with the patient in the supine position. The drug is administered as a bolus over a period of 15 to 30 seconds, with the patient remaining supine until all scheduled post injection blood samples have been taken. Blood pressure should be measured before TRH is administered and at frequent intervals during the first 15 minutes thereafter. Have the patient urinate before injecting TRH.

Previous work from our laboratory prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. In addition, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations.

Product name CAS Product name CAS
Abarelix Acetate 183552-38-7 Exenatide Acetate 141732-76-5
Alarelin Acetate 79561-22-1 GLP-1(7-36) 107444-51-9
Angiotensin Acetate 20071-00-5 Glucagon Acetate 16941-32-5
Antide Acetate 112568-12-4 Gonadorelin Acetate 34973-08-5
Argipressin Acetate 113-79-1 Goserelin Acetate 145781-92-6
Aviptadil Acetate 40077-57-4 Icatibant Acetate 30308-48-4
Bivalirudin Trifluoroacetate 128270-60-0 Leuprorelin 53714-56-0
buserelin Acetate 68630-75-1 Linaelotide Acetate 851199-59-2
Calcitonin salmon 47931-85-1 Lysipressin Acetate 50-57-7
Carperitide Acetate 89213-87-6 MOG (35-55) 149635-73-4
Cetrorelix acetate 120287-85-6 Nesiritide acetate 114471-18-0
Deslorelin Acetate 57773-65-6 Oxytocin Acetate 50-56-6
lcatonin Acetate 57014-02-5 Pramlintide acetate 196078-30-5
Eledoisin 69-25-0 TRH 24305-27-9
Enfuvirtide Acetate 159519-65-0 Secretin Acetate 17034-35-4
Eptifibatide Acetate 148031-34-9 Sermorelin Acetate 86168-78-7
Teriparatide Acetate 52232-67-4 Tetracosactide Acetate 16960-16-0

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