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Pharmaceutical Peptides

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Product Name:Setmelanotide

CAS:1294000-61-5

MF:C14H14ClF5N4O2S

MW:432.8

Setmelanotide, sold under the brand name Imcivree, is a medication used for the treatment of genetic obesity caused by a rare single-gene mutation.

The most common side effects include injection site reactions, skin hyperpigmentation (skin patches that are darker than surrounding skin), headache and gastrointestinal side effects (such as nausea, diarrhea, and abdominal pain), among others.Spontaneous penile erections in males and adverse sexual reactions in females have occurred with treatment.Depression and suicidal ideation have also occurred with setmelanotide.

Setmelanotide is indicated for chronic weight management (weight loss and weight maintenance for at least one year) in people six years and older with obesity due to three rare genetic conditions: pro-opiomelanocortin (POMC) deficiency, proprotein subtilisin/kexin type 1 (PCSK1) deficiency, and leptin receptor (LEPR) deficiency confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes considered pathogenic (causing disease), likely pathogenic, or of uncertain significance.Setmelanotide is the first FDA-approved treatment for these genetic conditions.

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