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Local Anesthetic Drugs

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  • Specifications
  • Product Description
  • Product Usage
  • COA

Product Name: Proparacaine hydrochloride
Synonyms: PROPARACAINE HCL;PROPARACAINE HYDROCHLORIDE;3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride;alcaine;benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride;benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,monohydrochlorid;beta-(diethylamino)ethyl3-amino-4-n-propoxybenzoatehydrochloride;chibro-heracaine
CAS: 5875-06-9
MF: C16H27ClN2O3
MW: 330.85
EINECS: 227-541-7
Usage Anesthetic;Neuronal conductance inhibitor

Proparacaine hydrochloride is an ester topical anesthetic. Its mechanism of action is to reduce the instantaneous permeability of neurons to sodium, stabilize nerve cell membranes, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia. Block pain fibers first, then block temperature, touch, and deep sensory fibers. Thin nerve fibers are more sensitive than thick nerve fibers and take longer to recover. The anesthetic strength of this medicine is slightly higher than the same concentration of tetracaine, and the effect is fast.

Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.

Test Items Standard Test Results
Character White crystalline powder Conforms
Identification IR

UV

The aqueous layer responds to the tests for

Chloride

Conforms

Conforms

Conforms

PH 4.5-6.0 5.8
Heavy metal Not more than 0.001% Conforms
Water 4.0%-6.0% 5.5%
Residue on ignition Not more than 0.1% 0.04%
Limit of residual solvents Not more than 2% Conforms
Chromatographic purity Total impurity:<2.0%

Individual impurity:<0.5%

Conforms

Conforms

Assay 98.5%-101.5% 99.50%
Conclusion It conforms to USP32 standard

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