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Local Anesthetic Drugs

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Name Propantheline
Synonyms [2-[(9H-Xanthen-9-ylcarbonyl)oxy]ethyl]diisopropylmethylaminium
CAS 298-50-0
Appearance White solid
Molecular Formula C16H26N2O3
Formula Weight 294.39
origin China
Assay 99%
Water <0.5%
application Pharmaceutical Intermediates

Proxymetacaine is a local anesthetic which on topical application penetrates sensory nerve endings in the corneal tissue.

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are.

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others. Proparacaine 0.5% is marketed as Poencaina by Poen Laboratories.

Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy.

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