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Local Anesthetic Drugs

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  • COA

English Synonyms: 2- (propylamino) propion-o-toluidide; N- (2-Methylphenyl) -2- (propylamino) propa-namide; Prilocaine base
CAS: 721-50-6
EINECS Number: 211-957-0
Formula: C13H20N2O
Molecular Weight: 220.31
Water solubility: soluble in water and ethanol, slightly soluble in chloroform
Assay:99%
Appearance: white crystalline powder

Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren.
In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.

Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy.

prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is used to prevent pain caused by an injection, the drawing of blood from a vein, or minor surgeries such as removing warts. This medicine contains a mixture of two topical local anesthetics. It deadens the nerve endings in the skin. Relieving pain of normal intact skin and numbing skin to pain from injections and other medical procedures. prilocaine cream is a local anesthetic. It works by blocking nerves from transmitting painful impulses to the brain Prilocaine Hydrochloride Injection, USP, 4% is a sterile, non pyrogenic isotonic solution that contains a local anesthetic agent and is administered parenterally by injection. See indications and usage for specific uses.

Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. Prilocaine crosses the blood-brain and placental barriers, presumably by passive diffusion. Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of prilocaine required to produce overt systemic effects. In the rhesus monkey, arterial blood levels of 20 mg/mL have been shown to be the threshold for convulsive activity.

Tests

Results

Specifications

Description

White crystalline powder

White or almost white crystalline powder
Solubility

Complies

Very soluble in alcohol and in acetone; slightly soluble in water.

Identification

Complies

By IR, to match with the working standard

Melting point

36.9℃~38.5℃ 36℃~39℃

Water

0.04% ≤0.5%

Residue on ignition

0.03% ≤0.1%

Related compound A

Complies

≤0.01%

Related compounds

0.05%

not more than 0.2% of any individual impurity

Complies

not more than one impurity exceeds 0.1%

0.15%

not more than 0.5% of total impurities

Residual solvents

Not detected

Dichloromethane Not more than0.06%

Not detected

Ethanol Not more than0.5%

0.03%

Isopropyl ether Not more than0.5%

Assay

99.27%

≥99.0%

Conclusion : Conforms to USP39

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