China Anabolic Steroids Powder Manufacturer
EnglishAfrikaansБългарскиNederlandsFrançaisDeutschItaliano日本語LatīnaNorskپارسیPolskiPortuguêsRomânăРусскийSlovenčinaSlovenščinaEspañolSvenskaTürkçeУкраїнськаудмурт кыл

Pharmaceutical Peptides

» Peptides » Pharmaceutical Peptides

  • Specifications
  • Product Description
  • Product Usage

Product Name : Ornipressin Acetate

Synonyms:8-Ornithine-vasopressin

CAS#: 3397-23-7; 914453-98-8

Molecular Formula: C45H63N13O12S2

MW: 1042.19

Sequence: H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)

Appearance: white powder

Purity (HPLC):≥98.0%

Single Impurity (HPLC): ≤2.0%

Acetate Content(HPLC): 5.0%-12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide content: ≥80.0%

Ornipressin is a synthetic derivative of vasopressin (arginine-8-vasopressin) in which ornithine is substituted for arginine at the 8 position. The basicity of the amino-acid residue at position 8 of the vasopressin molecule determines its pressor and anti-diuretic effect. Ornithine, being both less basic and a short-chain amino-acid, reduces the binding of ornipressin to the receptors in the distal tubule of the nephron without impairing its binding to the receptors in the vascular smooth muscle which mediate vasoconstriction. Thus, ornipressin has minimal antidiuretic activity whilst maintaining equipotent vasoconstrictor activity as the natural hormone, vasopressin.

Ornipressin, which has a high affinity for V1A receptors , activates Gs proteins, which stimulate phospholipase C and result in a breakdown of membrane lipids to inositol triphosphate (IP3) and diacylglycerol (DAG); IP3 releases calcium from the endoplasmic reticulum, thus increasing cytosolic calcium, while DAG activates protein kinase C which phosphorylates cellular proteins. This cascade of biochemical reactions leads to sustained vasoconstriction. However, at high concentrations (>0.1 IU mL−1), ornipressin binds to the V2 receptors when the V1A receptors are fully saturated. Activation of V2 receptors results in an increase in cyclic AMP which leads to vasodilatation, a paradoxical effect demonstrated by Fruhstorfer and Heisler.

Enquiry Form ( we will get back you as soon as possible )

Name:
*
Email:
*
Message:

Verification:
1 + 9 = ?

Maybe you like also

  • Our Advantage

    Good Price

    High Quality

    Fast Delivery

    Safe Shipment

    Excellent After-sale Service

  • Local Warehouse

    EU Warehouse

    UK Warehouse

    USA Warehouse

    Canada Warehouse

    Australia Warehouse

  • Payment Method

    Paypal

    Bitcoin

    Bank Wire

    Money Gram

    Western Union

  • Contact Us

    Email: jacob@steroid-peptide.com

    WhatsApp: +8615636286252

    Phone: 0086-15636286252

    Website: www.steroid-peptide.com

    Welcome your inquiry