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Active Pharmaceuticals

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  • Specifications
  • Product Description
  • Product Usage
  • COA

Chemical name:Mometasone Furoate
MF: C32H32Cl2O8
MW: 615.5
CAS: 83919-23-7
Purity: over 99%
Appearance: white powder
Usage: anti-inflammatory agent

Mometasone Furoate is the furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form)for patients unresponsive to less potent corticosteroids, and penile phimosis.In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.

Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis.Nasal mometasone is used in adults (including the elderly) and children over two years of age, to diminish the symptoms such as hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, and sneezing and to treat nasal polyps.

Items of analysis Specification Results
Description White to off-white powder Conform
Identification A:IR B:HPLC Conform
Melt Point About 220℃ 220.5℃
Specific Rotation +56 -+62 ° +58.4°
Loss on drying ≤0.5% 0.31%
Residue On Ignition ≤ 0.1% 0.08%
Heavy Metals ≤30 ppm Conform
Single impurity ≤1.0% Conform
Sum impurity ≤2.0% Conform
Assay 97-102% 99.36%
Particle size Micronized Conform
Conclusion Qualified

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