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Active Pharmaceuticals

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Product name Methylprednisolone acetate
CAS 53-36-1
MF C24H32O6
MW 416.51
Melting point 192-195°C
Boiling point 454.82°C (rough estimate)
Density 1.1156 (rough estimate)

Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic.

Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.

Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolon is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus.

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