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Female Steroids

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  • Specifications
  • Product Description
  • Product Usage
  • COA
Product name Megestrol Acetate
CAS No. 595-33-5
MF C24H32O4
MW 384.51
EINECS No. 209-864-5
Density 1.0474 (rough estimate)
Boiling Point 431.17°C (rough estimate)
Melting Point 214°C

Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.

(1). Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives.

(2). For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma.

(3).Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.

Items of analysis Specification Results
Characteristics White to creamy white, tasteless, the basic no smell of the crystalline powder Conforms
Identification Infrared absorption (IR) Conforms
Specific rotaion +8.8~+12° +11.74°
Melting point 213-220ºC 214.6~218.9ºC
Water ≤0.5% 012%
Residual on ignition ≤0.2% 0.11%
Heavy ≤0.002% Conforms
Organic volatile impurities Conforms to demand Conforms
Assay 97.0~103.0% 99.34%
Particle size 100%≤20μm 100%≤20μm
Conclusion Qualified

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