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Active Pharmaceuticals

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  • Specifications
  • Product Description
  • Product Usage
  • COA
Name Lincomycin Hydrochloride
Synonyms N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
Molecular Formula C18H35ClN2O6S
Molecular Weight 443
CAS Registry Number 859-18-7
EINECS Number 212-726-7
Melting point 156-158°C
Boiling point N/A
Solubility H2O: 50 mg/mL, clear, colorless
Density N/A

Lincomycin hydrochloride is a white crystalline powder with a slight or special odor at room temperature and a bitter taste. It is soluble in water or methanol and is commonly used in the form of hydrochloride in feed.

By acting on the 50S subunit of the sensitive bacteria ribosomes, it prevents the extension of the peptide chain, thus inhibiting the protein synthesis of bacterial cells, and has bacteriostatic effect, but it also has bactericidal effect on highly sensitive bacteria at high concentration.

It has strong antibacterial effect on gram-positive bacteria, some anaerobe and mildew, and its antibacterial spectrum is narrower than that of erythromycin.

Staphylococcus aureus, hemolytic streptococcus, pneumococcus and porcine pneumonia moldy body, chicken septicemia moldy body sensitive to this product, but enterococcus is generally resistant to this product.

Lincomycin HCL can be used as antibiotic drug for human and also can be used as veterinary medicine. It is primarily against gram-positive pathogens, and not effective against gram-negative bacteria such as Neisserie gonorrhoeae or Neisseria meningitidis,also used against susceptible strains of streptococci, pneumococci, and staphlylococci which usually can also be treated with penicillin or erythromycin.

Inspection items Test indicators inspection results
character Shall be white crystalline powder; Slight or special odor, bitter taste. White crystalline powder; Slight odor
Identify (1) the absorption spectrum of infrared light should be consistent with that of lincomycin hydrochloride The infrared absorption pattern of the sample was consistent with that of the control
(2) the retention time of the main peak of the test solution should be consistent with that of the control solution The main peak of the test solution was the same as that of the control solution.
Should be positive positive
check
crystalline Meet the regulations Conform
PH 3.0~5.5 4.6
The degree of solution clarification The solution should be clear and not darker than yellow or greenish-yellow no. 1 standard colorimetric solution. The solution is clear and colorless.
Water ≤6.0% 4.0%
On ignition residue ≤0.5% 0.1%
Bacterial endomycin Meet the regulations Conform
Lincomycin B ≤5.0% 2.8%
Residual organic solvent (n-butanol) ≤0.5% 0.0%
point Meet the regulations 6
Content ≥82.5% 89.4%

Conclusion

The product was tested in accordance with the Chinese pharmacopoeia 2010, and the results were in accordance with the regulations.

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