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Active Pharmaceuticals

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Product Name:(+)-Griseofulvin

Griseofulvin CAS:126-07-8

Griseofulvin MF:C17H17ClO6

Griseofulvin MW:352.77

Griseofulvin EINECS:204-767-4

Griseofulvin Purity:99%

Griseofulvin Appearance:light yellow powder

Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.

Griseofulvin has inhibitory effect to psoriasis skin fungus, Contains a list of the skin ringworm fungi genera,ringworm fungi genera and microspore bacteria. Of tinea versicolor bacterium, white beads bacterium and bacteria is invalid. This product on bacteriostasis, effective for vigorous growth of fungi.

Test Items Specification Test Results
Characteristics A yellowish-white,microfine powder yellowish-white,microfine powder
Melting point 220ºC About 220ºC 218.4ºC-219.4ºC
Specific optical rotation +354o~+364o +356o
Identification Meets the requirements Meets the requirements
Check-up Particles size Meets the requirements Meets the requirements
Acidity 0.25g consumed 0.02mol/l NaOH not more intensely coloured than reference solution Y4 0.6ml
Clarity and colour of solution The solution is clear and not more intensely coloured than reference solution Y4 Y5~Y6
Clear Y5~Y6
Matter soluble in petroleum spirit ≤0.2% 0.1%
Sulphated ash ≤0.2% 0.1%
Related substances -Cl:<0.60 -H<0.15 -Cl:0.48-H:0.04
Loss on drying ≤1.0% 0.1%
Abnormal toxicity Meets the requirements Meets the requirements
assay(on the anhydrous substance) 97.0%~102.0% 98.3%
Conclusion The above certificate of analysis is in compliance with BP/EP,meets the standard requirements.

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