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Female Steroids

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  • Specifications
  • Product Description
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  • COA
Product name Flurogestone Acetate
Other name Flugestone 17-Acetate; Fluorogesterone Acetate
CAS register number 2529-45-5
Molecular formula C23H31FO5
Molecular weight 406.49
Melting point 255-256.5°C
Assay 99%

Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. The use of SC-9880 in an intravaginal device for the control and synchronization of oestrus in sheep was described by Wishart.

Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 - 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges . A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates.

Product name Flurogestone acetate
Appearance White crystalline powder
Chromatographic purity Any individual impurity not more than 1.0%
Total impurities not more than 2.0%
0.4%
1.3%
Loss on drying Not more than 0.5% 0.2%
Residue on ignition Not more than 0.2% 0.03%
Residual solvents Methanol≤3000ppm
Methylene Chloride≤600ppm
Chloroform≤60ppm
Tetrahydrofuran≤720ppm
370ppm
Not detect out
Not detect out
Not detect out
Assay Between 97.0% and 102.0% 99.3%
Micronixation 90% not more than 10 microns 90% not more than 10
aicrons

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