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Active Pharmaceuticals

» Pharmaceuticals » Active Pharmaceuticals

  • Specifications
  • Product Description
  • Product Usage
  • COA

Name: Fluocinonide
CAS No.: 356-12-7
Formula: C26H32F2O7
Molecular Weight: 494.52
EINECS: 206-597-6
Density: 1.34 g/cm3
Melting Point: 309 °C
Boiling Point: 591.1 °C at 760 mmHg
Flash Point: 311.3 °C
Appearance: white crystalline powder

This product is a fluoride-containing glucocorticoid. Topical application can constrict dermal capillaries. Since it can inhibit DNA synthesis and affect cell metabolism, it can inhibit the proliferation or regeneration of epidermal cells. It can also inhibit the new generation of fibroblasts and the production of pigment cells in connective tissue. It can also stabilize the intracellular lysosomal membrane to prevent tissue damage caused by the release of histamine by intracellular lysosomal enzymes, and is easily absorbed from the skin for external use.

Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.

Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 2-4 times daily or as directed by your doctor. Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the eyes, nose, or mouth. If you get the medication in these areas, rinse with plenty of water.

Test Items Specifications Results

Appearance

White or almost white, crystalline powder

Conform

Identification
IR

The spectrum should be accord to the fluocinonide CRS

Conform

Test

Specific Optical Rotation

+81°~+89°(Dry)

+81°~+89°(dried substance)

+86.7°

Related Substances

Maximum single impurity ≤ 0.5 %

0.32%
≥0.5%Not more than one Conform

Total impurities≤ 2.0%

1.12%

Loss on drying

≤1.0% 0.11%

Content

(Dry)

97.0 percent to 103.0 percent (dried substance)

98.93%

Conclusion

To be conform with BP2015

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