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Active Pharmaceuticals

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  • Specifications
  • Product Description
  • Product Usage
  • COA
Product name Flumethasone
CAS No. 2135-17-3
MF C22H28F2O5
MW 410.45
EINECS No. 218-370-9
Density 1.1621 (estimate)
Boiling Point 569.8±50.0 °C(Predicted)
Melting Point 237-240°C

Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethason is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethason suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.

Items of analysis Specification Results
Description White crystalline powder White crystalline powder
Identification(HPLC) complies with the standard complies
Specific optical rotation +66º~+74º +71.9º
Loss on drying not more than 0.5% 0.06%
Impurity at RRT 1.11 not more than 0.15%
Impurity at RRT 1.39 not more than 0.15% 0.06%
Any unknoen Impurity not more than 0.2%
Total impurities not more than 1.0% 0.37%
Purity no less than 99.0% 99.6%
Conclusion Qualified

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