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Pharmaceutical Peptides

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Exenatide Acetate
Synonyms: Exendin-4 (Acetate)
CAS: 141732-76-5
MF: C186H284N50O62S
MW: 4244.60796
Purity : 99.0%min.
Appearance: White powder
Product Categories: Peptide;Agonist;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals

Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar CAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Exenatide Acetate is a polypeptide composed of 39 amino acids.It is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 value of 3.22 NM.

Application of exenatide acetate causes an increase in acinar CAMP without stimulating amylase release. As an incretin mimetic, exenatide acetate acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide acetate augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide acetate has found use as a medication of diabetes II.

Exenatide is a synthetic version of Exendin-4, an insulin secretagogue with glucoregulatory effects. It displays biological properties similar to human Glucagon-Like Peptide-1 (GLP-1), a regulator of glucose metabolism and insulin secretion. Exenatide enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.

Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content(Karl Fischer): ≤ 10.0%
Acetate Content(HPIC): ≤ 12.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%

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