| Product Name |
Elamipretide |
| Other names |
H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2; D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide |
| CAS Number |
736992-21-5 |
| PubChem CID |
11764719 |
| Formula |
C32H49N9O5 |
| Molar mass |
639.802 g·mol− |
Elamipretide is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inner mitochondrial membrane where it associates with cardiolipin. Through this mechanism of action, elamipretide is thought to restore energy production, to reduce the production of reactive oxygen species, and ultimately to increase the energy (adenosine triphosphate [ATP]) supplied to affected cells and organs.In preclinical studies, elamipretide increased the synthesis of ATP and reduced reactive oxygen species production regardless of the specific mitochondrial abnormality causing the impaired mitochondrial respiration.There is no observed effect on normally functioning mitochondria.
Elamipretide (also known as SS-31, , MTP-131 and Bendavia) is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.
Stealth Peptides, a privately held company, was founded in 2006 to develop intellectual property licensed from several universities including elamipretide; it subsequently changed its name to Stealth BioTherapeutics.
Product Name :Elamipretide
Synonyms: SS-31, MTP-131, Bendavia, RX-31
CAS#: 736992-21-5
Molecular Formula: C32H49N9O5
MW: 639.79
Sequence:H-D-Arg-(2´,6´-dimethyl-Tyr)-Lys-Phe-NH2
Appearance: white powder
Purity (HPLC):≥98.0%
Single Impurity (HPLC): ≤2.0%
Acetate Content(HPLC): 5.0%-12.0%
Water Content (Karl Fischer): ≤10.0%
Peptide content: ≥80.0%
