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Pharmaceutical Peptides

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Product Name:Dynorphin

Other Name:Dynorphin A (1-13)

CAS:72957-38-1

MF:C75H126N24O15

MW:1603.95

Dynorphin A is a dynorphin, an endogenous opioid peptide with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

Dynorphin A1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors,it has the highest binding affinity for the kappa-opioid receptor.

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time.

Dynorphin A (1-13) 72957-38-1 H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
(D-Arg6)-Dynorphin A (1-13) 75921-87-8 H-Tyr-Gly-Gly-Phe-Leu-D-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
(D-Arg8)-Dynorphin A (1-13) 125357-12-2 H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Arg-Arg-Pro-Lys-Leu-Lys-OH
Dynorphin A (2-17) 83608-80-4 H-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH

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