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Active Pharmaceuticals

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Product name Diclofenac Sodium
product alias armiel, dichlorominic pain
CAS 15307-79-6
EINECS no 239-346-4
Molecular formula C14H18C12N2O
Molecular weight 318.13
Content 98%
Properties colorless crystalline powder
Melting point 280-282
Solubility soluble in polar organic solvents such as water and ethanol.

Diclofenac sodium is sold under the brand names Cambia, Cataflam, Voltaren, Voltaren-XR and Zipsor. These medications are used to help relieve the symptoms of rheumatoid arthritis, osteoarthritis, pain, inflammation, swelling, stiffness and joint pain. In some cases, this medication will be used as part of a treatment regimen for ankylosing spondylitis, menstrual cramps or acute migraine attacks.

Diclofenac sodium is available in enteric coated tablets, extended release tablets, capsules, powder or solution, liquid filled capsule or a traditional tablet form. Dosing and instructions will vary based on the condition that is to be treated. You should not take more than instructed as this can lead to an increased risk of side effects. If you are using this medication for arthritis, you will usually be ordered to take this medication once a day for up to two weeks or until you begin to feel better. It may take several weeks until you feel the full effects of the medication.

1. Diclofenac sodium Solaraze is a non-steroidal anti-inflammatory drug, which has obvious analgesic, anti-inflammatory and antipyretic effects. Through inhibiting the cyclooxygenase and blocking the synthesis of prostaglandin and produce analgesia, anti-inflammatory, antipyretic effect.

2. Diclofenac sodium Solaraze has good anti-inflammatory and analgesic effects, can significantly relieve the following symptoms and effectively improve the function: pain at rest, pain during exercise, morning stiffness, joint edema.

3. Diclofenac sodium Solaraze can relieve rheumatoid arthritis and osteoarthritis. Spinal joint disease, gouty arthritis, rheumatoid arthritis and other chronic arthritis of the acute onset or persistent joint swelling pain symptoms. All kinds of soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise injury pain, etc. Acute mild to moderate pain such as: pain after surgery, trauma, strain, primary dysmenorrhea, toothache, headache, etc.

Item Standard Result
Characteristic Pure white crystalline powder, slightly

hygroscopic

Conforms
Solubility Sparingly soluble in water, freely soluble in methanol, ethanol (96%); slightly soluble in acetone;practically insoluble in ether Conforms
Identify (A) IR-Spectrum (A)conforms
(B) Reaction of sodium salt (B)Positive
PH 6.5~7.5 7.13
Appearance of solution Clear Conforms
Absorption of sodium salt≤0.05 0.015
Related substances Single impurity ≤0.2% Conforms
Total impurity ≤0.5%
Heavy metal ≤10ppm Conforms

 

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