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Active Pharmaceuticals

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Cabergoline Alias: Cabaser, Dostinex; Dostine, 6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
Cabergoline CAS: 81409-90-7
Cabergoline Molecular Formula: C26H37N5O2
Cabergoline Molecular Weight: 451.6
Cabergoline Melting Point: 102-104° C

The biggest reason why Cabergoline is admired by amateur and professional athletes is because it helps them reduce or eliminate the risks associated with excess prolactin that is common with use of harsh and aromatizable steroids like and Deca Durabolin. Furthermore, this drug is also useful for treating sexual dysfunction caused by excess prolactin besides gaining an erection between orgasms and reducing recovery time after intense workouts or weight training and strength training exercises. In addition to these advantages, the use of Dostinex is equally beneficial to combat estrogenic side effects such as oily skin, acne, gynecomastia, and bloating and treating health complications like galactorrhea and sexual dysfunction. It is also routinely indicated to patients with Parkinson's disease as it has the potential to work on information pathways and nervous system of the body. Dostinex is also admired for its ability to make athletes feel 'full' that helps in minimizing food cravings without dieting discomfort.

Cabergoline is used to treat different types of medical problems that occur when too much of the Hormone prolactin is produced. It can be used to treat certain menstrual problems, fertility problems. In men and women, and pituitary prolactinomas (tumors of the pituitary gland). It works by stopping. The brain from making and releasing the prolactin hormone from the pituitary Gland.

Cabergoline use is usually stopped when prolactin levels are normal for 6 months. It may be given again if symptoms of too much prolactin occur again. Originally introduced by the anti-aging community to the bodybuilding world, this dopamine receptor agonist has the chemical name of 1-[(6-allylergolin-8? -yl)-carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea and tablets of this drug include 0.5 mg of cabergoline and the list of inactive ingredients includes leucine, USP, lactose, and NF.

Dostinex, also called cabergoline (or just caber), is a dopamine agonist drug used in medicine, which is also popular in the bodybuilding world, where it is used to keep prolactin low during steroid cycles. Medically, it is used in males with hyperprolactinemia, reduced sperm production, impotency, and low sex drive.

Cabergoline is a dopamine agonist designed to reduce prolactin. In medical circles it is commonly used to combat prolactinomas, a benign tumor of the pituitary gland that may cause an excess production of prolactin. It is also used by athletes who supplement with anabolic steroids that may increase prolactin levels such as Nandrolone and Trenbolone.

ITEM LIMIT RESULT
Description White or almost white crystarlline powder Conforn
Identify 1. IR complies
2. X-Ray complies
3. HPLC complies
Conforn
Conforn
Conforn
Water No more than 0.5% 0.2%
Related substances 1.Allylamide (USP,rel,D) no more than 0.10%;
2. Allyl DHLA(USP,rel,D) no more than 0.15%;
3.Cabergoline oxide no more than 0.10%;
4.Other impurities individually no more than 0.10%;
5.Total no more than 0.50%.
0.02%
Less than 0.02%
Less than 0.02%
Less than 0.02%
0.05%
Assay(HPLC) 98.0-102.0% 100.5%
Opdical rotation -83.0 - -77.0 -78
Residual Solvents 1.Dichloromethane no more than 100ppm;
2.Acetone no more than200ppm;
3.Tert-butylmethylether no more than 200ppm;
4.Xylene no more than 1500ppm;
5.HEptane no more than 1000ppm;
Less than30ppm
Less than20ppm
Less than10ppm
110ppm
Less than30ppm
Residue on ignition NO more than0.10 % 0.02%
Heavy metals NO more than 20ppm 2ppm
Partcle size 90%af particles no mone than 80 Conform
Bulk Density 0.2~0.35g/em 0.33g/em
Conclusion Conform with EP6.0/ USP38 standard.

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