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Local Anesthetic Drugs

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CAS No.: 23964-57-0
M.F.: C13H21ClN2O3S
M.W.: 320.8354
Appearance: White crystalline powder
Model NO.:23964-57-0
Assay:99.5%
CAS:23964-57-0
Grade Standard:USP/BP

Articaine hydrochloride, its CAS NO. is 23964-57-0, the synonyms are 2-Thiophenecarboxylic acid,4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride ; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl ; Articaine HCl ; Methyl4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride ; Septanest ; Septocaine. Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.

(1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.

(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.

(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.

items tested specification result
description white or almost white crystalline powder white crystalline powder
solubility freely soluble in water and in alcohol complies
identification a,b,c,d complies
ph 4.2-5.2 4.90
appearance of solution solution should be clear complies
related substance impurity a ≤0.2%; any other impurity ≤0.1%; total of other impurities ≤0.5% not detected; 0.08%; 0.26%
heavy metals ≤5ppm <5ppm
loss on drying < 0.5% 0.09%
residue on ignition ≤0.1% 0.09%
organic residue complies complies
assay 98.5%-101.0% 99.60%
conclusion qualified

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