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Active Pharmaceuticals

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  • COA
English name: α-Arbutin
Appearance: White powder
Molecular Formula: C12H16O7
Molecular Weight: 272.2512
CAS: 84380-01-8
Purity: 99%
Odor: Characteristic

Alpha arbutin derived from bearberry leaves,a white needle crystal powder. Alpha arbutin used to inhibit the activity of tyrosinase in the body, prevent the formation of melanin, then reduce the skin pigment deposition, remove spots and freckles.Alpha-Arbutin is extracted from bearberry.Alpha-arbutin is a biosynthetic active ingredient that is pure, water-soluble and is manufactured in a powder form. As one of the most advanced skin lightening ingredients on the market, Alpha-Arbutin has been shown to work effectively on all skin types. Alpha arbutin powder also has sterilization, anti-inflammatory effect. Mainly used in high-end cosmetics.

1)cosmetic usage: skin whitening, anti- age effect and UVB/ UVC filter
a. Action Mechanism:
Arbutin can effectively inhibit the formation of melanin and the hyperpigmentation which caused by ultraviolet radiation. So it can be used to whiten skin, prevent the production of fliver spots and freckles, treat sunburn and regulate melanogenesis.

b. Application Methods:
Added to advanced cosmetics which function is lightening skin, sunscreen and dispelling freckle.
c. Reference Addition:0.5~3%

2)medical usage: an anti-inflammatory and antibacterial agent
a. ingredients for burns drugs : Arbutin is a new main ingredient for burns drug , characterized by rapid analgesic, anti-inflammatory and strong, rapid elimination of swelling, heal quickly, leaving no scars.

b. ingredients for intestinal anti-inflammatory drugs: bactericidal, anti-inflammatory effect, non-toxic side effects.

Items Specification Results
Appearance White crystalline powder White crystalline
Assay 99.50%Min 99.7%
Melting Point 199-201±0.5°C 199-201°C
Clarity of water solution Transparency, colorless,non suspended matters Pass
PH Value of 1% solution 5.0-7.0 5.56
Specific optical rotation -66±2° -67.6
IPV 1515cm-1 1220cm-1 1050cm-1

±(5-8)cm-1

Pass
Arsenic

Hydroquinone

2 ppm max

10ppm max

1.6

0.25

Heavy Metal 10ppm max 6.5
Loss on drying 0.5% max 0.39
Ignition Residue 0.5% max 0.25
Pathogen Bacteria: max 300CFU

Fungus:max 100CFU

<20

<20

Conclusion Conforms to standard

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