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Female Steroids

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Name:Allopregnan-3 alpha-ol-20-one
English Synonyms: Allopregnanolone(Brexanolone)
CAS Number: 516-54-1
Molecular formula: C21H34O2
Molecular weight: 318.49

Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone.As a medication, allopregnanolone is referred to as brexanolone, sold under the brand name Zulresso,and used to treat postpartum depression. It is used by injection into a vein over a 60-hour period under medical supervision.

Side effects of brexanolone may include sedation, sleepiness, dry mouth, hot flashes, and loss of consciousness.It is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).

Brexanolone was approved for medical use in the United States in 2019.The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.The long administration time, as well as the cost for a one-time treatment, have raised concerns about accessibility for many women.

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