Serilesine
Synonyms: Hexapeptide-10,Silitide
Formula: C28H53N7O8
Molecular:615.77
Sequence: H-Ser- Ile-Lys-Val-Ala-Val-OH
Purity (HPLC): 95.0% min.
Appearance :White powder
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content: ≤10.0%
Acetate Content: ≤15.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%
Storage: -20ºC; Store in a cool dry place
Usage: The skin is restructured, replenished (+19% of skin density after 2 months), firmer and more elastic, recovering its fullness.
Hexapeptide-10 is a synthetic peptide containing Alanine, Isoleucine, Lysine, Serine and Valine residues. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities.
Hexapeptide-10 promotes the rebuilding of collagens and helps reduce fine lines and pore size. It is a firming active that strengthens the dermo-epidermal junction.
The Hexapeptide-10 corresponds to residues 2099-2104 of the laminin α1 chain. Hexapeptide-10 has been shown to modulate tumor invasion, metastasis and angiogenesis. It also induced the synthesis of prostaglandin E2, interstitial collagenase, and gelatinase B in monocyte cell cultures. Laminin fragments containing the SIKVAV sequence may contribute to the inflammatory response at sites of wound healing. They may also play a role in the excessive induction of metalloproteinases in chronic inflammatory lesions.
Hexapeptide-10 is from an adhesion sequence of laminin, which restores the cutaneous structure.Hexapeptide-10 is a firming active that promotes a double-cellular activity on both keratinocytes and fibroblast. It increases the synthesis of laminin-5, alpha6-integrin and hemidesmosomes, thus strengthening the dermal-epidermal junction. With Hexapeptide-10,the skin is restructured, replenished, firmer and more elastic, recovering its fullness.
